Pro-healing protein release from 3D-printed „smart“ hydrogel carriers applicable in regenerative medicine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU142486" target="_blank" >RIV/00216305:26620/21:PU142486 - isvavai.cz</a>
Result on the web
<a href="https://www.mrs-serbia.org.rs/files/YUCOMAT-2021.pdf" target="_blank" >https://www.mrs-serbia.org.rs/files/YUCOMAT-2021.pdf</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Pro-healing protein release from 3D-printed „smart“ hydrogel carriers applicable in regenerative medicine
Original language description
In recent years, there has been an increase in the use of 3D printing technologies in regenerative medicine to produce medical implants. This work deals with the 3D printing of a hydrogel carrier based on itaconyl-modified PLGA-PEG-PLGA thermosensitive copolymer, which can be crosslinked with blue light in the presence of a water-soluble nontoxic photoinitiator. The copolymer for 3D printing is water soluble, and bioresorbable in the human body. The printing process was performed by direct ink writing method at ambient temperature between 20-40 °C to avoid bioactive substances damage (e.g., growth factors) incorporated into the copolymer water solution before the printing process. A thermostable 9-point mutant of fibroblast growth factor 2 (FGF2-STAB®., Enantis L.t.d.) was chosen as the ideal bioactive component for its ability to support the growth and the formation of new vessels (angiogenesis), leading to improved wound healing, tissue regeneration and contributes to the pathogenesis of several di
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/EF19_073%2F0016948" target="_blank" >EF19_073/0016948: Quality internal grants at BUT</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů