„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU142383" target="_blank" >RIV/00216305:26620/21:PU142383 - isvavai.cz</a>
Result on the web
<a href="https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html" target="_blank" >https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release
Original language description
There is a strong emphasis on controlled drug delivery systems at this time. In this work stable Fibroblast growth factor 2 (FGF2-stab), developed by the Enantis company (Brno, CZ), was used as a protein-based drug. FGF2-stab stimulates the growth and the development of new vessels (angiogenesis), leading to improved wound healing, tissue development and contributes to the pathogenesis of several diseases (cancer or atherosclerosis). Amphiphilic PLGA-PEG-PLGA triblock copolymer was used as the biodegradable water-soluble copolymer that undergoes to a gel at physiological temperature. Along with increasing temperature in an aqueous environment, the PLGA-PEG-PLGA copolymer forms micelles having the hydrophobic core (PLGA) and the hydrophilic shell surface (PEG). Nowadays, drug carriers based on PLGA-PEG-PLGA copolymers are already commercially available under the names ReGel® and OncoGel® loaded with insulin or paclitaxel, respectively.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/EF19_073%2F0016948" target="_blank" >EF19_073/0016948: Quality internal grants at BUT</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů