Implications of unconventional setting conditions on the mechanical strength of synthetic bone grafts produced with self-hardening calcium phosphate pastes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU143385" target="_blank" >RIV/00216305:26620/22:PU143385 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S027288422103580X?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S027288422103580X?pes=vor</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ceramint.2021.11.163" target="_blank" >10.1016/j.ceramint.2021.11.163</a>
Alternative languages
Result language
angličtina
Original language name
Implications of unconventional setting conditions on the mechanical strength of synthetic bone grafts produced with self-hardening calcium phosphate pastes
Original language description
Work presents the effects of several factors on the mechanical strength of a calcium phosphate cement (CPC) based on alpha tricalcium phosphate and correlates the results with the microstructure and percentage of conversion to hydroxyapatite. Conversion rate increased by raising the setting temperature in the studied range (4–90 °C), but the strength exhibited an increasing-decreasing trend due to changes in the morphology of hydrated crystals. Plate-like crystals were formed in the range of 22–60 °C, mechanically reinforcing the material, whereas the formation and refinement of needle-like crystals at higher setting temperature decreased the strength. Moreover, cements with dissimilar particle sizes had different optimal hydrolysis temperatures that resulted in the maximum strength. The finest powder led to higher strength at lower setting temperature due to the formation of a more compact crystal network and higher conversion. Therefore, optimization of powder particle size may allow to achieve the highest possible strength at room temperature, being beneficial for the production of the strongest pre-set CPC-based implants without the use of energy. Furthermore, the particle size can be also engineered to produce formulations that develop the highest strength at physiological temperature, with application as injectable bone grafts. The incorporation and crosslinking of gelatine further increased the mechanical strength of pre-set cements by bridging the hydroxyapatite crystals, the setting temperature showing a similar effect to that of gelatine-free cements. In contrast, moisture decreased the strength and reduced the brittleness by solvating intramolecular association between hydroxyapatite crystals and between gelatine molecules. Moreover, large cement bodies were slightly weaker than small ones, but the size effect was not statistically significant.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ceramics International
ISSN
0272-8842
e-ISSN
1873-3956
Volume of the periodical
48
Issue of the periodical within the volume
2022
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
6225-6235
UT code for WoS article
000752868900003
EID of the result in the Scopus database
2-s2.0-85121275317