The Effect of the Thermosensitive Biodegradable PLGA-PEG-PLGA Copolymer on the Rheological, Structural and Mechanical Properties of Thixotropic Self-Hardening Tricalcium Phosphate Cement
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F19%3A00518447" target="_blank" >RIV/67985891:_____/19:00518447 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/19:PU130827 RIV/68378041:_____/19:00518447 RIV/68407700:21220/19:00328689 RIV/65269705:_____/19:00070511
Result on the web
<a href="https://www.mdpi.com/1422-0067/20/2/391" target="_blank" >https://www.mdpi.com/1422-0067/20/2/391</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms20020391" target="_blank" >10.3390/ijms20020391</a>
Alternative languages
Result language
angličtina
Original language name
The Effect of the Thermosensitive Biodegradable PLGA-PEG-PLGA Copolymer on the Rheological, Structural and Mechanical Properties of Thixotropic Self-Hardening Tricalcium Phosphate Cement
Original language description
The current limitations of calcium phosphate cements (CPCs) used in the field of bone regeneration consist of their brittleness, low injectability, disintegration in body fluids and low biodegradability. Moreover, no method is currently available to measure the setting time of CPCs in correlation with the evolution of the setting reaction. The study proposes that it is possible to improve and tune the properties of CPCs via the addition of a thermosensitive, biodegradable, thixotropic copolymer based on poly(lactic acid), poly(glycolic acid) and poly(ethylene glycol) (PLGA-PEG-PLGA) which undergoes gelation under physiological conditions. The setting times of alpha-tricalcium phosphate (-TCP) mixed with aqueous solutions of PLGA-PEG-PLGA determined by means of time-sweep curves revealed a lag phase during the dissolution of the -TCP particles. The magnitude of the storage modulus at lag phase depends on the liquid to powder ratio, the copolymer concentration and temperature. A sharp increase in the storage modulus was observed at the time of the precipitation of calcium deficient hydroxyapatite (CDHA) crystals, representing the loss of paste workability. The PLGA-PEG-PLGA copolymer demonstrates the desired pseudoplastic rheological behaviour with a small decrease in shear stress and the rapid recovery of the viscous state once the shear is removed, thus preventing CPC phase separation and providing good cohesion. Preliminary cytocompatibility tests performed on human mesenchymal stem cells proved the suitability of the novel copolymer/-TCP for the purposes of mini-invasive surgery.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
<a href="/en/project/NV18-05-00379" target="_blank" >NV18-05-00379: Development and comprehensive evaluation of novel injectable, resorbable, porous bone substitute with controlled release of antimicrobial agents</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
391
UT code for WoS article
000459746500159
EID of the result in the Scopus database
2-s2.0-85060165680