Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU144964" target="_blank" >RIV/00216305:26620/22:PU144964 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adfm.202200691" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adfm.202200691</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.202200691" target="_blank" >10.1002/adfm.202200691</a>
Alternative languages
Result language
angličtina
Original language name
Laser-Driven Wireless Deep Brain Stimulation using Temporal Interference and Organic Electrolytic Photocapacitors
Original language description
Deep brain stimulation (DBS) is a technique commonly used both in clinical and fundamental neurosciences. Classically, brain stimulation requires an implanted and wired electrode system to deliver stimulation directly to the target area. Although techniques such as temporal interference (TI) can provide stimulation at depth without involving any implanted electrodes, these methods still rely on a wired apparatus which limits free movement. Herein organic photocapacitors as untethered light-driven electrodes which convert deep-red light into electric current are reported. Pairs of these ultrathin devices can be driven using lasers at two different frequencies to deliver stimulation at depth via temporally interfering fields. This concept of laser TI stimulation using numerical modeling, tests with phantom brain samples, and finally in vivo tests is validated. Wireless organic photocapacitors are placed on the cortex and elicit stimulation in the hippocampus, while not delivering off-target stimulation in the cortex. This laser-driven wireless TI evokes a neuronal response at depth that is comparable to control experiments induced with deep brain stimulation protocols using implanted electrodes. This work shows that a combination of these two techniques-temporal interference and organic electrolytic photocapacitors-provides a reliable way to target brain structures requiring neither deeply implanted electrodes nor tethered stimulator devices. The laser TI protocol demonstrated here addresses two of the most important drawbacks in the field of DBS and thus holds potential to solve many issues in freely moving animal experiments or for clinical chronic therapy application.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ADVANCED FUNCTIONAL MATERIALS
ISSN
1616-301X
e-ISSN
1616-3028
Volume of the periodical
32
Issue of the periodical within the volume
33
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
„2200691-1“-„2200691-8“
UT code for WoS article
000804989000001
EID of the result in the Scopus database
2-s2.0-85131179700