Non-invasive temporal interference electrical stimulation of the human hippocampus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079712" target="_blank" >RIV/00159816:_____/23:00079712 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00133407
Result on the web
<a href="https://www.nature.com/articles/s41593-023-01456-8" target="_blank" >https://www.nature.com/articles/s41593-023-01456-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41593-023-01456-8" target="_blank" >10.1038/s41593-023-01456-8</a>
Alternative languages
Result language
angličtina
Original language name
Non-invasive temporal interference electrical stimulation of the human hippocampus
Original language description
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NATURE NEUROSCIENCE
ISSN
1097-6256
e-ISSN
1546-1726
Volume of the periodical
26
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
24
Pages from-to
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UT code for WoS article
001085953500003
EID of the result in the Scopus database
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