SiO2 Fibers of Two Lengths and Their Effect on Cellular Responses of Macrophage-like Cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU145648" target="_blank" >RIV/00216305:26620/22:PU145648 - isvavai.cz</a>

Alternative codes found

RIV/00216275:25310/22:39919120

Result on the web

<a href="https://www.mdpi.com/1420-3049/27/14/4456" target="_blank" >https://www.mdpi.com/1420-3049/27/14/4456</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules27144456" target="_blank" >10.3390/molecules27144456</a>

Result language

angličtina

Original language name

SiO2 Fibers of Two Lengths and Their Effect on Cellular Responses of Macrophage-like Cells

Original language description

The immunoreactivity or/and stress response can be induced by nanomaterials' different properties, such as size, shape, etc. These effects are, however, not yet fully understood. This study aimed to clarify the effects of SiO2 nanofibers (SiO(2)NFs) on the cellular responses of THP-1-derived macrophage-like cells. The effects of SiO(2)NFs with different lengths on reactive oxygen species (ROS) and pro-inflammatory cytokines TNF-alpha and IL-1 beta in THP-1 cells were evaluated. From the two tested lengths, it was only the L-SiO(2)NFs with a length approximate to 44 +/- 22 mu m that could induce ROS. Compared to this, only S-SiO(2)NFs with a length approximate to 14 +/- 17 mu m could enhance TNF-alpha and IL-1 beta expression. Our results suggested that L-SiO(2)NFs disassembled by THP-1 cells produced ROS and that the inflammatory reaction was induced by the uptake of S-SiO(2)NFs by THP-1 cells. The F-actin staining results indicated that SiO(2)NFs induced cell motility and phagocytosis. There was no difference in cytotoxicity between L- and S-SiO(2)NFs. However, our results suggested that the lengths of SiO(2)NFs induced different cellular responses.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Project

<a href="/en/project/EF17_048%2F0007421" target="_blank" >EF17_048/0007421: Strengthening interdisciplinary cooperation in research of nanomaterials and their effects on living organisms (NANOBIO)</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MOLECULES

ISSN

1420-3049

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

14

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

„4456“-„“

UT code for WoS article

000831360700001

EID of the result in the Scopus database

2-s2.0-85135134080