Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU147268" target="_blank" >RIV/00216305:26620/22:PU147268 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adhm.202200075" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adhm.202200075</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adhm.202200075" target="_blank" >10.1002/adhm.202200075</a>
Alternative languages
Result language
angličtina
Original language name
Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields
Original language description
Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 - 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Interconnection Networks
ISSN
2192-2640
e-ISSN
2192-2659
Volume of the periodical
11
Issue of the periodical within the volume
17
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
„“-„“
UT code for WoS article
000821632800001
EID of the result in the Scopus database
2-s2.0-85133499259