Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU147335" target="_blank" >RIV/00216305:26620/23:PU147335 - isvavai.cz</a>

Alternative codes found

RIV/00216224:90242/23:00133733 RIV/62156489:43210/23:43922565

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1002/admi.202201996" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/admi.202201996</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/admi.202201996" target="_blank" >10.1002/admi.202201996</a>

Result language

angličtina

Original language name

Silver Nanoparticle-Decorated Reduced Graphene Oxide Nanomaterials Exert Membrane Stress and Induce Immune Response to Inhibit the Early Phase of HIV-1 Infection

Original language description

Graphene-based 2D nanomaterials exhibit unique physicochemical, electric, and optical properties that facilitate applications in a wide range of fields including material science, electronics, and biotechnology. Recent studies have shown that graphene oxide (GO) and reduced graphene oxide (rGO) exhibit antimicrobial effects on bacteria and viruses. While the bactericidal activity of graphene-based nanomaterials is related to mechanical and oxidative damage to bacterial membranes, their antiviral activity has been less explored. Currently available experimental data are limited and suggest mechanical disruption of viral particles prior to infection. In this study, the antiviral properties of reduced GO-based nanocomposites decorated with Ag nanoparticles (rGO-Ag) are evidenced against human immunodeficiency virus-1 pseudovirus used as an enveloped virus model. By combining biochemical and original single virus imaging approaches, it is shown that rGO-Ag induces peroxidation of pseudoviral lipid membrane and that consequent alteration of membrane properties leads to a reduction in cell entry. In addition, rGO-Ag is found to be efficiently internalized in the host cell leading to the elevated expression of pro-inflammatory cytokines. Altogether, the presented results shed new light on the mechanisms of rGO-Ag antiviral properties and confirm the high potential of graphene derivatives as an antimicrobial material for biomedical applications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10400 - Chemical sciences

Project

<a href="/en/project/EF16_025%2F0007314" target="_blank" >EF16_025/0007314: Multidisciplinary research to increase application potential of nanomaterials in agricultural practice</a><br>

Continuities

—

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advanced Materials Interfaces

ISSN

2196-7350

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

15

Pages from-to

1-15

UT code for WoS article

000895508500001

EID of the result in the Scopus database

2-s2.0-85144083695