Imaging the elemental distribution within human malignant melanomas using Laser-Induced Breakdown Spectroscopy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU151784" target="_blank" >RIV/00216305:26620/24:PU151784 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43927031 RIV/00216208:11150/24:10480850 RIV/00179906:_____/24:10480850
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0003267024004641" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0003267024004641</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aca.2024.342663" target="_blank" >10.1016/j.aca.2024.342663</a>
Alternative languages
Result language
angličtina
Original language name
Imaging the elemental distribution within human malignant melanomas using Laser-Induced Breakdown Spectroscopy
Original language description
The diagnosis of malignant melanoma, often an inconspicuous but highly aggressive tumor, is most commonly done by histological examination, while additional diagnostic methods on the level of elements and molecules are constantly being developed. Several studies confirmed differences in the chemical composition of healthy and tumor tissue. Our study presents the potential of the LIBS (Laser -Induced -Breakdown Spectroscopy) technique as a diagnostic tool in malignant melanoma (MM) based on the quantitative changes in elemental composition in cancerous tissue. Our patient group included 17 samples of various types of malignant melanoma and one sample of healthy skin tissue as a control. To achieve a clear perception of results, we have selected two biogenic elements (calcium and magnesium), which showed a dissimilar distribution in cancerous tissue from its healthy surroundings. Moreover, we observed indications of different concentrations of these elements in different subtypes of malignant melanoma, a hypothesis that requires confirmation in a more extensive sample set. The information provided by the LIBS Imaging method could potentially be helpful not only in the diagnostics of tumor tissue but also be beneficial in broadening the knowledge about the tumor itself.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Analytica Chimica Acta
ISSN
0003-2670
e-ISSN
1873-4324
Volume of the periodical
1310
Issue of the periodical within the volume
6
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
1-8
UT code for WoS article
001242653300001
EID of the result in the Scopus database
2-s2.0-85192805169