Assessing spatial distribution of bioindicator elements in various cutaneous tumors using correlative imaging with laser-ablation-based analytical methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU152248" target="_blank" >RIV/00216305:26620/24:PU152248 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43927435 RIV/00216208:11150/24:10483386 RIV/00179906:_____/24:10483386
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0039914024010300?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0039914024010300?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.talanta.2024.126651" target="_blank" >10.1016/j.talanta.2024.126651</a>
Alternative languages
Result language
angličtina
Original language name
Assessing spatial distribution of bioindicator elements in various cutaneous tumors using correlative imaging with laser-ablation-based analytical methods
Original language description
Correlative imaging of cutaneous tumors provides additional information to the standard histopathologic examination. However, the joint progress in the establishment of analytical techniques, such as Laser-Induced Breakdown Spectroscopy (LIBS) and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICPMS) in clinical practice is still limited. Their combination provides complementary information as it is also shown in our study in terms of major biotic (Ca, Mg, and P) and trace (Cu and Zn) elements. To elucidate changes in the elemental composition in tumors, we have compiled a set of malignant tumors (Squamous Cell Carcinoma, Basal Cell Carcinoma, Malignant Melanoma, and Epithelioid Angiosarcoma), one benign tumor (Pigmented Nevus) and one healthy-skin sample. The data processing was based on a methodological pipeline involving binary image registration and affine transformation. Thus, our paper brings a feasibility study of a practical methodological concept that enables us to compare LIBS and LA-ICP-MS results despite the mutual spatial distortion of original elemental images. Moreover, we also show that LIBS could be a sufficient pre-screening method even for a larger number of samples according to the speed and reproducibility of the analyses. Whereas LA-ICP-MS could serve as a ground truth and reference technique for preselected samples.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GA22-27580S" target="_blank" >GA22-27580S: Laser spectroscopy for nanometal-based label assays and imaging</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
TALANTA
ISSN
0039-9140
e-ISSN
1873-3573
Volume of the periodical
279
Issue of the periodical within the volume
126651
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
„“-„“
UT code for WoS article
001292188400001
EID of the result in the Scopus database
2-s2.0-85200497214