Porous silica-doped calcium phosphate scaffolds prepared via in-situ foaming method
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU152330" target="_blank" >RIV/00216305:26620/24:PU152330 - isvavai.cz</a>
Alternative codes found
RIV/68081723:_____/24:00599161 RIV/00216224:14110/24:00136681 RIV/65269705:_____/24:00080312 RIV/00159816:_____/24:00080312
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0272884224033790?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0272884224033790?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ceramint.2024.07.433" target="_blank" >10.1016/j.ceramint.2024.07.433</a>
Alternative languages
Result language
angličtina
Original language name
Porous silica-doped calcium phosphate scaffolds prepared via in-situ foaming method
Original language description
The effect of silica (SiO2) addition (0 wt%-20 wt%) on the microstructural and mechanical properties, as well as the in vitro response of calcium phosphate scaffolds for potential application in bone tissue engineering (BTE) was investigated in this research. Scaffolds characterized by high porosity (77%-88 %) and interconnected spherical pores with a broad range of pore sizes (5-600 mu m) were fabricated using in-situ foaming method. Incorporated silica affected the phase transformation of hydroxyapatite (HA) to beta-tricalcium phosphate (beta-TCP) and led to the development of new crystalline silica-rich phases like silicocarnotite and wollastonite. The reinforcement of silica became apparent during the tests of mechanical properties. Scaffolds with 5 wt% of SiO2 exhibited compressive strength (1.13 MPa) higher than pure HA scaffolds (0.93 MPa). Bone bonding potential of the materials was tested in simulated body fluid (SBF), demonstrating this potential in silica-doped samples. Additionally, degradation experiments showed gradual material degradation, making it suitable for BTE applications. Furthermore, cell culture studies using human mesenchymal stromal cells (MSC) confirmed the scaffold's non- toxicity and provided insights into how the silica content influences cell viability, morphology, and osteogenic potential. The findings of this study offer valuable insights into the design and development of advanced scaffolds with tailored properties for effective BTE applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20504 - Ceramics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CERAMICS INTERNATIONAL
ISSN
0272-8842
e-ISSN
1873-3956
Volume of the periodical
50
Issue of the periodical within the volume
21
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
41215-41227
UT code for WoS article
001327513100001
EID of the result in the Scopus database
2-s2.0-85200225907