Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081723%3A_____%2F22%3A00559864" target="_blank" >RIV/68081723:_____/22:00559864 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/22:00077643 RIV/00216305:26620/22:PU144304 RIV/00216224:14110/22:00126583
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/21870764.2022.2053278" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/21870764.2022.2053278</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/21870764.2022.2053278" target="_blank" >10.1080/21870764.2022.2053278</a>
Alternative languages
Result language
angličtina
Original language name
Macroporous bioceramic scaffolds based on tricalcium phosphates reinforced with silica: microstructural, mechanical, and biological evaluation
Original language description
The positive effect of silica on microstructural, mechanical and biological properties of calcium phosphate scaffolds was investigated in this study. Scaffolds containing 3D interconnected spherical macropores with diameters in the range of 300-770 mu m were prepared by the polymer replica technique. Reinforcement was achieved by incorporating 5 to 20 wt % of colloidal silica into the initial hydroxyapatite (HA) powder. The HA was fully decomposed into alpha and beta-tricalcium phosphate, and silica was transformed into cristobalite at 1200 degrees C. Silica reinforced scaffolds exhibited compressive strength in the range of 0.3 to 30 MPa at the total porosity of 98-40%. At a nominal porosity of 75%, the compressive strength was doubled compared to scaffolds without silica. When immersed into a cultivation medium, the formation of an apatite layer on the surfaces of scaffolds indicated their bioactivity. The supportive effect of the silicon enriched scaffolds was examined using three different types of cells (human adipose-derived stromal cells, L929, and ARPE-19 cells). The cells firmly adhered to the surfaces of composite scaffolds with no sign of induced cell death. Scaffolds were non-cytotoxic and had good biocompatibility in vitro. They are promising candidates for therapeutic applications in regenerative medicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20504 - Ceramics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Asian Ceramic Societies
ISSN
2187-0764
e-ISSN
2187-0764
Volume of the periodical
10
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
356-369
UT code for WoS article
000773431900001
EID of the result in the Scopus database
2-s2.0-85127222302