Enhancing the substrate selectivity of enzyme mimetics in biosensing and bioassay: Novel approaches

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU152475" target="_blank" >RIV/00216305:26620/24:PU152475 - isvavai.cz</a>
Alternative codes found
RIV/67985882:_____/24:00588276 RIV/62156489:43210/24:43925274 RIV/CZ______:_____/24:N0000053
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0001868624001568?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0001868624001568?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cis.2024.103233" target="_blank" >10.1016/j.cis.2024.103233</a>

Result language
angličtina
Original language name
Enhancing the substrate selectivity of enzyme mimetics in biosensing and bioassay: Novel approaches
Original language description
A substantial development in nanoscale materials possessing catalytic activities comparable with natural enzymes has been accomplished. Their advantages were owing to the excellent sturdiness in an extreme environment, possibilities of their large-scale production resulting in higher profitability, and easy manipulation for modification. Despite these advantages, the main challenge for artificial enzyme mimetics is the lack of substrate selectivity where natural enzymes flourish. This review addresses this vital problem by introducing substrate selectivity strategies to three classes of artificial enzymes: molecularly imprinted polymers, nanozymes (NZs), and DNAzymes. These rationally designed strategies enhance the substrate selectivity and are discussed and exemplified throughout the review. Various functional mechanisms associated with applying enzyme mimetics in biosensing and bioassays are also given. Eventually, future directives toward enhancing the substrate selectivity of biomimetics and related challenges are discussed and evaluated based on their efficiency and convenience in biosensing and bioassays.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics

Project
<a href="/en/project/EF16_025%2F0007314" target="_blank" >EF16_025/0007314: Multidisciplinary research to increase application potential of nanomaterials in agricultural practice</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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