Enhancement of biocompatibility of anodic nanotube structures on biomedical Ti-6Al-4V alloy via ultrathin TiO₂ coatings

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0198094" target="_blank" >RIV/00216305:26620/26:0198094 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1515810/full" target="_blank" >https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2024.1515810/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fbioe.2024.1515810" target="_blank" >10.3389/fbioe.2024.1515810</a>

Result language

angličtina

Original language name

Enhancement of biocompatibility of anodic nanotube structures on biomedical Ti-6Al-4V alloy via ultrathin TiO₂ coatings

Original language description

This work aims to describe the effect of the surface modification of TiO2 nanotube (TNT) layers on Ti-6Al-4V (TiAlV) alloy by ultrathin TiO2 coatings prepared via Atomic Layer Deposition (ALD) on the growth of MG-63 osteoblastic cells. The TNT layers with two distinctly different inner diameters, namely similar to 15 nm and similar to 50 nm, were prepared via anodic oxidation of the TiAlV alloy. Flat, i.e., non-anodized, TiAlV alloy foils were used as reference substrates. Additionally, a part of the TNT layers and alloy foils was coated with ultrathin coatings of TiO2 by ALD. The number of TiO2 ALD cycles used was 1 and 5 leading to a nominal TiO2 thickness of similar to 0.055 and similar to 0.3 nm, respectively. The ultrathin TiO2 coating by ALD enabled to optimize the surface hydrophilicity for optimal cell growth. In addition, coatings shaded impurities of V- and F-based species (stemming from the alloy and the anodization electrolyte) that affect the biocompatibility of the tested materials while preserving the original structure and morphology. The evaluation of the biocompatibility before and after TiO2 ALD coating on TiAlV flat surfaces and TNT layers was carried out using MG-63 osteoblastic cells and compared after incubation for up to 96 h. The cell growth, adhesion, and proliferation of the MG-63 on TiAlV foils and TNT layers showed significant enhancement after the surface modification by TiO2 ALD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20800 - Environmental biotechnology

Project

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Continuities

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Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Bioengineering and Biotechnology

ISSN

2296-4185

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

1515810

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

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UT code for WoS article

001378695000001

EID of the result in the Scopus database

2-s2.0-85212076032