Nanorobot-Cell Communication via <i>In Situ</i> Generation of Biochemical Signals: Toward Regenerative Therapies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0198687" target="_blank" >RIV/00216305:26620/26:0198687 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsnano.5c02092" target="_blank" >https://pubs.acs.org/doi/10.1021/acsnano.5c02092</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsnano.5c02092" target="_blank" >10.1021/acsnano.5c02092</a>
Alternative languages
Result language
angličtina
Original language name
Nanorobot-Cell Communication via <i>In Situ</i> Generation of Biochemical Signals: Toward Regenerative Therapies
Original language description
Achieving precise control of cellular processes drives possibilities for next-generation therapeutic approaches. However, existing technologies for influencing cell behavior primarily rely on specific drug delivery, limiting their ability to mimic natural cellular communication processes. In this work, we developed glucose-powered gold-silica (Au-SiO2) nanorobots that induce cell migration by generating steady-state hydrogen peroxide (H2O2) as a biochemical signaling molecule to mimic natural cellular communication with high spatial resolution. These nanorobots leverage the unique 2-in-1 catalytic activity of gold nanoparticles for glucose oxidation and H2O2 decomposition, allowing for precise control over the generation of steady-state H2O2 concentration and enhanced diffusion powered by glucose within the cellular microenvironment. We further demonstrated that at low dosages of nanorobots, the steady-state H2O2 generation promotes cell migration and proliferation, while higher dosages of nanorobots slow down cell proliferation. The proposed design of this biocompatible nanorobot is intended to enable communication with the environment and provide a noninvasive, biochemical command system for regulating cellular behavior. Additionally, we show proof of principle of a method by which nanorobots can augment wound healing and similar regenerative therapies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
<a href="/en/project/LM2023050" target="_blank" >LM2023050: National Infrastructure for Biological and Medical Imaging</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Nano
ISSN
1936-0851
e-ISSN
1936-086X
Volume of the periodical
19
Issue of the periodical within the volume
25
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
22953-22967
UT code for WoS article
001514177100001
EID of the result in the Scopus database
2-s2.0-105008311484