Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00635683" target="_blank" >RIV/68378041:_____/25:00635683 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10515639 RIV/61989100:27240/25:10257743 RIV/00216305:26620/26:0198219
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsnano.4c18874" target="_blank" >https://pubs.acs.org/doi/10.1021/acsnano.4c18874</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsnano.4c18874" target="_blank" >10.1021/acsnano.4c18874</a>
Alternative languages
Result language
angličtina
Original language name
Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair
Original language description
Corneal repair using mesenchymal stem cell therapy faces challenges due to long-term cell survival issues. Here, we design cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for treating corneal damage in a synergistic combination with stem cells. Powered by glucose, CeSAN-bots exhibit enhanced diffusion and active motion due to the cascade reaction catalyzed by gold and cerium oxide. CeSAN-bots demonstrate a two-fold increase in cellular uptake efficiency into mesenchymal stem cells compared to passive uptake. CeSAN-bots possess intrinsic antioxidant and immunomodulatory properties, promoting corneal regeneration. Validation in a mouse corneal alkali burn model reveals an improvement in corneal clarity restoration when stem cells are incorporated with CeSAN-bots. This work presents a strategy for developing glucose-driven, enzyme-free, single-atom-based ultrasmall nanorobots with promising applications in targeted intracellular delivery in diverse biological environments.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30207 - Ophthalmology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Nano
ISSN
1936-0851
e-ISSN
1936-086X
Volume of the periodical
19
Issue of the periodical within the volume
20
Country of publishing house
US - UNITED STATES
Number of pages
21
Pages from-to
19095-19115
UT code for WoS article
001487304800001
EID of the result in the Scopus database
2-s2.0-105005323219