Biomimetic pHEMA Hydrogels as an Alternative Cartilage-like Model Material for Biotribological Evaluations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0199016" target="_blank" >RIV/00216305:26620/26:0199016 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsomega.5c05569" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.5c05569</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.5c05569" target="_blank" >10.1021/acsomega.5c05569</a>
Alternative languages
Result language
angličtina
Original language name
Biomimetic pHEMA Hydrogels as an Alternative Cartilage-like Model Material for Biotribological Evaluations
Original language description
Poly(vinyl alcohol) (PVA) has been widely explored as a model material for articular cartilage (AC) in biotribological evaluations. However, PVA hydrogels prepared by freeze-thawing or cast-drying methods have limitations in precisely controlling their elasticity parameters and may require reinforcement to enhance their mechanical performance and change their transparency, required in some tribological measurement setups by using fluorescence methods. To overcome these issues, poly(hydroxyethyl methacrylate) (pHEMA) hydrogels have been introduced as alternatives. In our study, pHEMA hydrogels synthesized using free-radical polymerization with blue light under two different atmospheres (nitrogen N2 and air) were compared with natural samples of articular bovine cartilage. The optical, mechanical, swelling, and tribological properties demonstrate the superior properties of pHEMA, which may result in the replacement of the currently used PVA-based model in future studies. Synthesis under a nitrogen atmosphere (pHEMA N 2) resulted in the formation of smooth-surfaced hydrogels, whereas synthesis under a laboratory atmosphere (pHEMA air) resulted in the formation of wrinkled-surfaced hydrogels. The swelling of both the hydrogels and AC followed first-order kinetics. Pin-on-plate biotribology measurements showed that the coefficient of friction of the wrinkled-surface hydrogels resembled that of AC. Our results showed that pHEMA-based hydrogels are suitable biotribological AC models for a better understanding of the biological functions of bovine AC. This knowledge brings new insights into cartilage complex mechanisms and might be applied in both biomedical and engineering applications.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/EH22_008%2F0004634" target="_blank" >EH22_008/0004634: Mechanical engineering of biological and bio-inspired systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Omega
ISSN
2470-1343
e-ISSN
2470-1343
Volume of the periodical
10
Issue of the periodical within the volume
38
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
44147-44161
UT code for WoS article
001571666200001
EID of the result in the Scopus database
2-s2.0-105017408200