Engineering Two-in-One Nanoparticles for Simultaneous Delivery of Graphene Quantum Dot and Pemetrexed
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F26%3A0200718" target="_blank" >RIV/00216305:26620/26:0200718 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/25:00142461
Result on the web
<a href="https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c07253?utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://pubs.acs.org/doi/pdf/10.1021/acsomega.5c07253?utm_source=clarivate&getft_integrator=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.5c07253" target="_blank" >10.1021/acsomega.5c07253</a>
Alternative languages
Result language
angličtina
Original language name
Engineering Two-in-One Nanoparticles for Simultaneous Delivery of Graphene Quantum Dot and Pemetrexed
Original language description
The simultaneous delivery of therapeutic agents and imaging probes using polymeric nanoparticles (NPs) has gained significant attention for cancer treatment. In this work, we developed a multifunctional nanocarrier system composed of an amphiphilic block copolymer, poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone) (PEtOx-b-PCL), and dimethyldidodecylammonium bromide (DDAB), for the codelivery of the chemotherapeutic drug pemetrexed (PMT) and nitrogen- or sulfur-doped graphene quantum dots (N-GQDs or S-GQDs) as fluorescent probes. Critical formulation parameters were optimized using a central composite design (CCD). The optimized NPs exhibited favorable physicochemical properties, including positive surface charge (6-8 mV), hydrodynamic diameters of similar to 140 nm, and high encapsulation efficiency for both PMT (46-56%) and GQDs (>98%). In vitro assays revealed that PMT-loaded nanoparticles (NPs) significantly enhanced cytotoxicity against MCF-7 cells. At a concentration of 2 ppm after 72 h, N-PMT NPs and S-PMT NPs inhibited cell proliferation by 50.7% and 53.8%, respectively, compared to 37.8% inhibition with free PMT at the same dose. Confocal microscopy confirmed efficient intracellular uptake and strong fluorescence signals, supporting their potential for bioimaging. Collectively, these results demonstrate that this two-in-one nanocarrier system significantly enhances chemotherapeutic efficacy while enabling real-time imaging, establishing a promising platform for drug delivery and noninvasive treatment monitoring in cancer nanomedicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10400 - Chemical sciences
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Omega
ISSN
2470-1343
e-ISSN
2470-1343
Volume of the periodical
10
Issue of the periodical within the volume
41
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
48934-48947
UT code for WoS article
001589675200001
EID of the result in the Scopus database
2-s2.0-105019071166