Haematological malignancies in sibling and unrelated donors of allogeneic peripheral stem cells mobilised with G-CSF filgrastim: a transplant centre and Czech National Marrow Donors Registry experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F12%3A10135328" target="_blank" >RIV/00669806:_____/12:10135328 - isvavai.cz</a>

Result on the web

<a href="http://www.nature.com/bmt/journal/v47/n6/pdf/bmt2011173a.pdf" target="_blank" >http://www.nature.com/bmt/journal/v47/n6/pdf/bmt2011173a.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/bmt.2011.173" target="_blank" >10.1038/bmt.2011.173</a>

Result language

angličtina

Original language name

Haematological malignancies in sibling and unrelated donors of allogeneic peripheral stem cells mobilised with G-CSF filgrastim: a transplant centre and Czech National Marrow Donors Registry experience

Original language description

G-CSF filgrastim is frequently used to mobilise CD34? cells in donors before PBSC collection. Several observational reports raised concerns regarding an elevated risk of haematological malignancies after G-CSF administration. It was found that treatmentwith G-CSF of PBSC donors induced chromosomal tetraploidy in a small subset of mature myeloid cells in the blood,1 epigenetic and genetic alterations in lymphocytes2 and aneuploidy.3 In 2006, Bennett et al.4 reported two cases of AML identified in the sibling donors, whose recipients also suffered with AML, among 200 individuals who had received filgrastim before collection of PBSC for allogeneic transplantation. In a large retrospective EBMT analysis, Halter et al.5 observed 20 haematological malignancies (3.92/10 000), of which 12 were after donating PBSC; however, the observed incidence rate did not exceed the expected incidence in an age- and sex-adjusted general population, and there was no relationship with the type of haematologi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bone Marrow Transplantation

ISSN

0268-3369

e-ISSN

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Volume of the periodical

47

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

2

Pages from-to

867-868

UT code for WoS article

000305276200016

EID of the result in the Scopus database

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