Outcomes of 167 healthy sibling donors after peripheral blood stem cell mobilization with G-CSF 16 mu g/kg/day: efficacy and safety

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00084608" target="_blank" >RIV/00216224:14110/15:00084608 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/15:00063399

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2015_094" target="_blank" >http://dx.doi.org/10.4149/neo_2015_094</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2015_094" target="_blank" >10.4149/neo_2015_094</a>

Result language

angličtina

Original language name

Outcomes of 167 healthy sibling donors after peripheral blood stem cell mobilization with G-CSF 16 mu g/kg/day: efficacy and safety

Original language description

Mobilization of peripheral blood stem cells (PBSC) using the granulocyte colony-stimulating factor (G-CSF) has enabled the collection even from older donors and those with comorbidities. Several clinical parameters have been reported to predict the success of PBSC mobilization. The aim of our study was to evaluate the safety of PBSC donation in a cohort of 167 sibling donors after mobilization with G-CSF 16 mu g/kg/day for 5 days during short- and long term follow-up and to analyse the efficacy, toxicity and factors influencing CD34+ mobilization capacity. All 167 sibling donors completed the established mobilization protocol. The median yield was 7.9x10(6)CD34 cells/kg per recipient weight. The optimal target dose of CD34 cells &gt;= 4.0x10(6)/kg wasachieved in 140 donors (84%). Only in 4 donors (2%) was the CD34+ yield &lt; 2x10(6)/kg. No major toxicities occured. Factors associated with higher PBSC yields included age &lt; 55 years (p=0.001), male gender (p=0.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

5

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

787-792

UT code for WoS article

000362389600013

EID of the result in the Scopus database

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