Cytarabine plus G-CSF is more effective than cyclophosphamide plus G-CSF as a stem cell mobilization regimen in multiple myeloma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA20021XJ" target="_blank" >RIV/61988987:17110/19:A20021XJ - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41409-018-0396-x" target="_blank" >https://www.nature.com/articles/s41409-018-0396-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41409-018-0396-x" target="_blank" >10.1038/s41409-018-0396-x</a>
Alternative languages
Result language
angličtina
Original language name
Cytarabine plus G-CSF is more effective than cyclophosphamide plus G-CSF as a stem cell mobilization regimen in multiple myeloma
Original language description
Cyclophosphamide (Cy) plus granulocyte-colony stimulating factor (G-CSF) is currently a standard regimen for hematopoietic stem cell (HSC) mobilization in patients with multiple myeloma (MM). However, cytarabine (AraC) in intermediate doses plus G-CSF seems to have a higher mobilization efficacy. The aim of this study was to retrospectively compare mobilization using AraC and Cy. Thirty consecutive MM patients were mobilized by Cy + G-CSF, and the subsequent 40 patients by AraC + G-CSF. Both groups were comparable. The target yield of 10 x 10(6) CD34+ cells/kg (for tandem and 2 additional transplantations) was achieved in 98% (AraC) and 57% (Cy) of patients (p < 0.0001) by 1.2 and 2.1 apheresis (means), and by single apheresis in 83 and 17% of patients, respectively. AraC mobilization resulted in higher peak concentration of CD34+ cells in blood (median 238.0 vs. 87.9/mu L, p < 0.0001) and higher CD34+ yield (median 28.6 x 10(6) vs. 10.4 x 10(6)/kg, p < 0.0001) compared to Cy mobilization. Toxicities were comparable except for thrombocytopenia gr. 4, observed in 50% of patients after AraC (Cy 7%). In view of these results, we conclude that mobilization with AraC plus G-CSF is very effective with acceptable toxicity and could be considered in MM patients with planned or expected higher numbers of transplantations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BONE MARROW TRANSPL
ISSN
0268-3369
e-ISSN
1476-5365
Volume of the periodical
54
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
1107
Pages from-to
1114-7
UT code for WoS article
000473724200021
EID of the result in the Scopus database
2-s2.0-85056829713