Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F16%3A10323173" target="_blank" >RIV/00669806:_____/16:10323173 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/16:10323173
Result on the web
<a href="http://dx.doi.org/10.3892/ijo.2016.3484" target="_blank" >http://dx.doi.org/10.3892/ijo.2016.3484</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ijo.2016.3484" target="_blank" >10.3892/ijo.2016.3484</a>
Alternative languages
Result language
angličtina
Original language name
Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy
Original language description
MicroRNAs have the potential to become valuable predictive markers for gastric cancer. Samples of biopsy tissue, routinely taken from gastric cancer patients undergoing pallia-tive chemotherapy, constitute suitable material for microRNA profiling with the aim of predicting the effect of chemotherapy. Our study group consisted of 54 patients, all of whom under-went palliative chemotherapy based on 5-fluorouracil (5-FU) or 5-FU in combination with platinum derivatives between 2000 and 2013. The expression of 29 selected microRNAs and genes BRCA1, ERCC1, RRM1 and TS, in gastric cancer tissue macrodissected from FFPE tissue samples, was measured by quantitative RT-PCR. The relationship between gene expres-sion levels and time to progression (TTP) and overall survival (OS) was analysed. In routinely available FFPE tissue samples, we found 6 miRNAs with a relation to TTP, which may serve as predictors of the effectiveness of palliative treatment in gastric cancer patients. These miRNAs could also help in deciding whether to indicate palliative chemotherapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14227" target="_blank" >NT14227: Determining predictive factors for a therapeutic effect of chemotherapy in patients with stomach cancer</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Oncology
ISSN
1019-6439
e-ISSN
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Volume of the periodical
48
Issue of the periodical within the volume
6
Country of publishing house
GR - GREECE
Number of pages
11
Pages from-to
2693-2703
UT code for WoS article
000375807900047
EID of the result in the Scopus database
2-s2.0-84964612274