Liver status and outcomes in patients without previous known liver disease receiving anticoagulant therapy for venous thromboembolism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10439488" target="_blank" >RIV/00669806:_____/22:10439488 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=DkIP07G2Sw" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=DkIP07G2Sw</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11739-021-02858-x" target="_blank" >10.1007/s11739-021-02858-x</a>
Alternative languages
Result language
angličtina
Original language name
Liver status and outcomes in patients without previous known liver disease receiving anticoagulant therapy for venous thromboembolism
Original language description
The association between elevated liver enzymes or FIB-4 (fibrosis index 4) and outcome in patients with venous thromboembolism (VTE) has not been evaluated. Data from patients in RIETE (Registro Informatizado Enfermedad TromboEmbólica) were used to assess the association between elevated liver enzymes or FIB-4 levels and the rates of major bleeding or death in apparent liver disease-free patients with acute VTE under anticoagulation therapy. A total of 6206 patients with acute VTE and without liver disease were included. Of them, 92 patients had major bleeding and 168 died under anticoagulation therapy. On multivariable analysis, patients with elevated liver enzymes were at increased mortality risk (HR: 1.58; 95% CI: 1.10-2.28), while those with FIB-4 levels > 2.67 points were at increased risk for major bleeding (HR: 1.69; 95% CI: 1.04-2.74). Evaluation of liver enzymes and FIB-4 index at baseline in liver disease-free patients with VTE may provide additional information on the risk for major bleeding or death during anticoagulation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Internal and Emergency Medicine
ISSN
1828-0447
e-ISSN
1970-9366
Volume of the periodical
17
Issue of the periodical within the volume
3
Country of publishing house
IT - ITALY
Number of pages
10
Pages from-to
725-734
UT code for WoS article
000705823900001
EID of the result in the Scopus database
2-s2.0-85116816148