Oncogenic Fusions in Gliomas: An Institutional Experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10443302" target="_blank" >RIV/00669806:_____/22:10443302 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/22:10443302

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=62TRz08_Iq" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=62TRz08_Iq</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.15671" target="_blank" >10.21873/anticanres.15671</a>

Result language

angličtina

Original language name

Oncogenic Fusions in Gliomas: An Institutional Experience

Original language description

Background/Aim: Gliomas are primary malignancies of the central nervous system (CNS). High-grade gliomas are associated with poor prognosis and modest survival rates despite intensive multimodal treatment strategies. Targeting gene fusions is an emerging therapeutic approach for gliomas that allows application of personalized medicine principles. The aim of this study was to identify detectable fusion oncogenes that could serve as predictors of currently available or newly developed targeted therapeutics in cross-sectional samples from glioma patients using next-generation sequencing (NGS). Patients and Methods: A total of 637 patients with glial and glioneuronal tumours of the CNS who underwent tumour resection between 2017 and 2020 were enrolled. Detection of fusion transcripts in FFPE tumour tissue was performed by a TruSight Tumour 170 assay and two FusionPlex kits, Solid Tumour and Comprehensive Thyroid and Lung. Results: Oncogene fusions were identified in 33 patients. The most common fusion was the KIAA1549-BRAF fusion, detected in 13 patients, followed by TACC3, FGFR3-Co5, FGFR3-AMBRA1), identified in 10

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

1791-7530

Volume of the periodical

42

Issue of the periodical within the volume

4

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

1933-1939

UT code for WoS article

000778640800004

EID of the result in the Scopus database

2-s2.0-85127263366