Protein expression and localization of ABC transporters in pancreatic adenocarcinoma: prognostic role of ABCC8
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F23%3A10469365" target="_blank" >RIV/00669806:_____/23:10469365 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/23:43926107 RIV/00216208:11140/23:10469365 RIV/61989592:15110/23:73621204
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=uyDTqvsQm-" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=uyDTqvsQm-</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pan.2023.10.008" target="_blank" >10.1016/j.pan.2023.10.008</a>
Alternative languages
Result language
angličtina
Original language name
Protein expression and localization of ABC transporters in pancreatic adenocarcinoma: prognostic role of ABCC8
Original language description
Background: ATP-binding cassette (ABC) transporters translocate various substances across cellular membranes. Their deregulation may cause cancer drug resistance or perturbations in the supply of building blocks for cancer cells and modify patients' prognosis. This study investigated protein expression and cellular localization of the previously suggested putative prognostic biomarkers - ABCB2/TAP1, ABCC7/CFTR, ABCC8/SUR1, and ABCD4 in patients with pancreatic ductal adenocarcinoma (PDAC).Methods: Protein expression and localization were assessed by immunohistochemistry in formalin-fixed paraffin-embedded primary tumor tissue blocks of 61 PDAC patients and associated with clinical data and the survival of patients.Results: No CFTR protein expression was observed in PDAC, while TAP1 and ABCC8 were expressed predominantly in the cytoplasm of tumor cells. Most samples (81%) had detectable both membranous and cytoplasmic ABCD4 staining and 42% had ABCD4 expressed in the apical orientation. Negative membranous ABCD4 staining was significantly more frequent in advanced stage III or IV tumors (p=0.022). Small or medium counts of individual ABCC8-positive cells in the stroma surrounding tumor tubules were also more often found in stage III or IV (p=0.044). Patients with moderate or strong ABCC8 cytoplasmic staining intensity in tumor cells had a 3.5-fold higher risk of disease progression than those with weak staining (p=0.002).Conclusions: The study shows for the first time that the cytoplasmic ABCC8 protein expression has prognostic value in PDAC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pancreatology
ISSN
1424-3903
e-ISSN
1424-3911
Volume of the periodical
23
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
978-987
UT code for WoS article
001136921700001
EID of the result in the Scopus database
2-s2.0-85173838860