Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F25%3A10501176" target="_blank" >RIV/00669806:_____/25:10501176 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/25:10501176
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vsWZ1GB56p" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vsWZ1GB56p</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ncrna.2025.07.006" target="_blank" >10.1016/j.ncrna.2025.07.006</a>
Alternative languages
Result language
angličtina
Original language name
Non-viral HCC miRNA profiling reveals miR-1972 as a potential positive prognostic marker
Original language description
Background & Aims: Hepatocellular carcinoma (HCC) is the third deadliest cancer worldwide. Its high mortality is primarily attributed to late-stage diagnosis. While mutations in driver genes, such as those encoding β-catenin (CTNNB1), tumor protein p53 (TP53), and telomerase reverse transcriptase promoter (TERTp) are well-documented in the literature, dysregulation of microRNAs (miRNAs), small non-coding RNAs that serve as crucial translational regulators, remains poorly understood. Methods: We conducted microRNA profiling by microarrays in 45 paired (tumor and non-tumor adjacent tissue) samples from non-viral HCC patients. We performed clinical correlation, ROC analysis and survival analysis of time to recurrence (TTR), disease-free survival (DFS) and overall survival. Results: We identified 23 significantly dysregulated miRNAs (p <= 0.05, fold change >=2). We investigated their differential expression and its relationship with clinical and pathological variables. Further, we found that miRNA-1972 may serve as an important positive prognostic marker because its high levels were associated with longer TTR and DFS. Significant positive results were obtained in receiver operating characteristic analysis for miR-1972, miR-3651 and miR-486-5p. Conclusion: miRNA-1972 is a strong prognostic marker in non-viral HCC. Dysregulation of several other miRNAs relates to pathological variables such as amount of stroma within tumor, microvascular invasion and micronodularity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Non-coding RNA Research
ISSN
2468-2160
e-ISSN
2468-0540
Volume of the periodical
15
Issue of the periodical within the volume
December
Country of publishing house
IN - INDIA
Number of pages
8
Pages from-to
100-107
UT code for WoS article
001577029500001
EID of the result in the Scopus database
2-s2.0-105013465475