CTNNB1 mutations, TERT polymorphism and CD8+cell densities in resected hepatocellular carcinoma are associated with longer time to recurrence
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F75010330%3A_____%2F22%3A00013870" target="_blank" >RIV/75010330:_____/22:00013870 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/22:10445899 RIV/00216208:11120/22:43923762
Result on the web
<a href="https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09989-0" target="_blank" >https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09989-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12885-022-09989-0" target="_blank" >10.1186/s12885-022-09989-0</a>
Alternative languages
Result language
angličtina
Original language name
CTNNB1 mutations, TERT polymorphism and CD8+cell densities in resected hepatocellular carcinoma are associated with longer time to recurrence
Original language description
Background: Hepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alterations in telomerase reverse transcriptase promoter (TERTp) and beta-catenin (CTNNB1) genes and immune cell activation in the tumor microenvironment. As a novel approach, we wanted to assess patient survival influenced by combined presence of mutations and densities of CD8+ cytotoxic T cells. Methods: Tissue samples were obtained from 67 HCC patients who had undergone resection. We analysed CD8+ T cells density, TERTp mutations, rs2853669 polymorphism, and CTNNB1 mutations. These variables were evaluated for time to recurrence (TTR) and disease free survival (DFS). Results: TERTp mutations were found in 75.8% and CTNNB1 mutations in 35.6% of the patients. TERTp mutations were not associated with survival but polymorphism rs2853669 in TERTp was associated with improved TTR and DFS. CTNNB1 mutations were associated with improving TTR. High density of CD8(+) T-Iymphocytes in tumor center and invasive margin correlated with longer TTR and DFS. Combined genetic and immune factors further improved survival showing higher predictive values. E.g., combining CTNNB1 mutations and high density of CD8+ T-Iymphocytes in tumor center yielded HRs of 0.12 (0.03-0.52), p = 0.005 for TTR and 0.25 (0.09-0.74), p = 0.01 for DFS. Conclusion: The results outline a novel integrative approach for prognostication through combining independent predictive factors from genetic and immune cell profiles. However, larger studies are needed to explore multiple cell types in the tumor microenvironment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Cancer
ISSN
1471-2407
e-ISSN
1471-2407
Volume of the periodical
22
Issue of the periodical within the volume
August
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
884
UT code for WoS article
000840098000002
EID of the result in the Scopus database
2-s2.0-85135843340