Prolyl-hydroxyproline dipeptide in non-hydrolyzed morning urine and its value in postmenopausal osteoporosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F08%3A00016006" target="_blank" >RIV/00843989:_____/08:00016006 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/08:00326361

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Prolyl-hydroxyproline dipeptide in non-hydrolyzed morning urine and its value in postmenopausal osteoporosis

Original language description

High correlation between the level of prolyl-4-hydroxyproline dipeptide in non-hydrolyzed urine and that of 4-hydroxyproline in hydrolyzed urine might reveal the dipeptide as a valuable osteomarker. Based on densitometry, 68 postmenopausal women were divided into group of non-osteopathic, osteopenic and osteoporotic subjects. The dipeptide and current urinary resorption markers were assayed in morning urine, serum formation markers by means of immunoassay procedures. Along with the assay of the basal levels, diet-related changes and the healing effect of yearly alendronate therapy were assessed. Concentration levels in controls and osteoporotic subjects differed significantly; ROC analysis gave sensitivity of 0.743 and cut-off 10.2 ?mol/mmol of creatinine. Diet-related changes were not found. Following the therapy, a significant decline occurred already within a trimester. The ease of the dipeptide assay surpass that of hydroxyproline, the dipeptide can serve as a valuable osteomarker.

Czech name

Dipeptid prolyl-hydroxyprolin v nehydrolyzované moči a jeho význam v postmenopausální osteoporóze

Czech description

Vysoká korelace mezi hladinou dipeptidu prolyl-4-hydroxyprolin v nehydrolyzované moči a 4-hydroxyprolinu v moči po hydrolýze ukazuje na možný význam dipeptidu jako markeru kostní resorpce. Skupina 68 žen po menopauze byla rozdělena na základě denzitometrie do 3 skupin, kontrolní, ostopenií a osteopatií. Dipeptid a zavedené močové markery resorpce byly stanoveny v ranní moči, sérové markery kostní formace byly stanoveny imunochemicky. Spolu s bazálními hladinami byl sledován vliv diety a roční terapie alendronáty. Hladiny dipeptidu ve skupině kontrol a osteopatií se významně lišily, ROC analýza poskytla hodnotu sensitivity 0,743 a cut-off 10,2 ?mol/mmol kreatininu. Ovlivnění dietou nebylo prokázáno. Významný pokles hladiny dipeptidu nastal již po 3 měsících terapie. Snadnost stanovení dipeptidu v nehydrolyzované moči je významným zlepšením oproti stanovení hydroxyprolinu a látka byla potvrzena jako hodnotný osteomarker.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NR8948" target="_blank" >NR8948: Simple and inexpensive screening of PRO-HYP dipeptide in non-hydrolyzed urine and its assumed significant role as a biomarker of bone resorption</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Chemistry and Laboratory Medicine

ISSN

1434-6621

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

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UT code for WoS article

000259929400008

EID of the result in the Scopus database

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