Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9691" target="_blank" >RIV/00216208:11110/11:9691 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22310/11:43892010 RIV/00064165:_____/11:9691 RIV/61388971:_____/11:00377560 RIV/61388955:_____/11:00377560

Result on the web

<a href="http://dx.doi.org/10.2486/indhealth.MS1237" target="_blank" >http://dx.doi.org/10.2486/indhealth.MS1237</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

Original language description

Exhaled breath condensate (EBC) is assumed to reflect processes in the lungs, yet it is unknown whether oxidative stress markers in EBC are affected by systemic disorders (atherosclerosis, hypertension, diabetes) or whether lung diseases increase markersin plasma and urine. 8-isoprostane, 4-hydroxy-trans-2-nonenale (HNE) and malondialdehyde (MDA) were measured using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) in EBC, plasma and urine in 82 patients (45 with asbestosisand hyalinosis, and 37 with silicosis) and in 29 control subjects. 8-isoprostane and HNE in EBC, and HNE in urine were higher in both groups of patients. In addition, 8-isoprostane in plasma and urine, and MDA in urine were higher in asbestos-exposed patients and MDA in plasma in silicotics, with this marker in plasma correlated with the grade of silicosis. In all subjects, 8-isoprostane in EBC correlated with urine (r=0.38, p<0.001) and plasma levels (r=0.28, p=0.003), and HNE and MDA

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Industrial Health

ISSN

0019-8366

e-ISSN

—

Volume of the periodical

49

Issue of the periodical within the volume

6

Country of publishing house

JP - JAPAN

Number of pages

9

Pages from-to

746-754

UT code for WoS article

000297605600009

EID of the result in the Scopus database

—