Subgroups of the BENEFIT study: risk of developing MS and treatment effect of interferon beta-1b
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F08%3A00103096" target="_blank" >RIV/00843989:_____/08:00103096 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00415-007-0733-2" target="_blank" >http://dx.doi.org/10.1007/s00415-007-0733-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00415-007-0733-2" target="_blank" >10.1007/s00415-007-0733-2</a>
Alternative languages
Result language
angličtina
Original language name
Subgroups of the BENEFIT study: risk of developing MS and treatment effect of interferon beta-1b
Original language description
Background The BENEFIT study examined interferon beta (IFNB)-1b treatment in patients with clinically isolated syndrome (CIS) and >= 2 clinically silent brain MRI lesions. Methods Subgroups of 468 patients (IFNB-1b: n = 292; placebo: n = 176) were created for demographics, clinical, laboratory, and MRI findings at onset. The 'natural' risk of clinically definite MS (CDMS) over 2 years was estimated by Kaplan Meier statistics in placebo-treated patients; the IFNB-1b treatment effect was analysed by Cox proportional hazards regression. Results The risk of CDMS was increased in placebotreated patients (overall 45 %) if they were younger (< 30 years: 60%), were cerebrospinal fluid (CSF)-positive (49 %), or had received steroid treatment (48 %). MRI parameters implied a higher risk in placebo-treated patients with >= 9 T2-lesions (48%) or >= 1 gadolinium (Gd)-enhancing lesions (52 %). The CDMS risk was highest (75 %) in placebo-treated patients with monofocal disease onset displaying MRI di
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of neurology
ISSN
0340-5354
e-ISSN
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Volume of the periodical
255
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
480-487
UT code for WoS article
000255255300002
EID of the result in the Scopus database
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