CCND1 and ZNF217 gene amplification is equally frequent in BRCA1 and BRCA2 associated and non-BRCA breast cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00101134" target="_blank" >RIV/00843989:_____/10:00101134 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/10:A11010J5 RIV/00216224:14110/10:00051817 RIV/00209805:_____/10:#0000271

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

CCND1 and ZNF217 gene amplification is equally frequent in BRCA1 and BRCA2 associated and non-BRCA breast cancer

Original language description

We determined whether there was any difference in CCND1 and ZNF217 gene amplification with respect to BRCA status. There were 15 and 9 samples from BRCA1 and BRCA2 mutation carriers, respectively, and 16 from patients without mutation. Fluorescence in situ hybridization showed that eight tumors exhibited CCND1 amplification. ZNF217 amplification was observed in three of 38 cases. There was no significant difference in CCND1 and ZNF217 amplification between BRCA1, BRCA2 and non-BRCA tumors. CCND1 amplification was associated with decreased disease-free (P = 0.045) and overall survival (P = 0.015). BRCA1 tumors with CCND1 amplification were estrogen receptor negative. All ZNF217 amplified tumors were of the medullary histological type (P = 0.002). Therewas no statistical correlation between CCND1 and ZNF217 amplification and estrogen receptor, progesterone receptor, and ERBB2 expression and TNM classification. CCND1 amplification did not correlate with EGFR expression.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NR9092" target="_blank" >NR9092: Germline mutations of PML gene in patients with cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

4

Country of publishing house

SK - SLOVAKIA

Number of pages

8

Pages from-to

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UT code for WoS article

000278262000006

EID of the result in the Scopus database

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