Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F10%3A00101546" target="_blank" >RIV/00843989:_____/10:00101546 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/10:#0001172 RIV/61989592:15110/10:33117968
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe
Original language description
The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0 MHz frequency in Doppler mode. Sixteen AISpatients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 +/- 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 +/- 7.9y) were randomized for sono-thrombolysis (8+ 8 patients) or standard treatment (control group) (8+8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and alpha-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found aftersono-thrombolysis when compared with control group (p<0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thromb
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NR9487" target="_blank" >NR9487: Activation of fybrinolytic system using continual sonography monitoring in acute stroke patients and in volunteers</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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