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Hyperfractionated accelerated radiotherapy with concomitant integrated boost of 70-75 Gy in 5 weeks for advanced head and neck cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F12%3A00102810" target="_blank" >RIV/00843989:_____/12:00102810 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064211:_____/12:#0000214

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s00066-012-0128-x" target="_blank" >http://dx.doi.org/10.1007/s00066-012-0128-x</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00066-012-0128-x" target="_blank" >10.1007/s00066-012-0128-x</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Hyperfractionated accelerated radiotherapy with concomitant integrated boost of 70-75 Gy in 5 weeks for advanced head and neck cancer

  • Original language description

    The present study was performed to evaluate the feasibility of a new, 5-week regimen of 70-75 Gy hyperfractionated accelerated radiotherapy with concomitant integrated boost (HARTCIB) for locally advanced, inoperable head and neck cancer. A total of 39 patients with very advanced, stage IV nonmetastatic head and neck squamous cell carcinoma (median gross tumor volume 72 ml) were included in this phase I dose escalation study. A total of 50 fractions intensity-modulated radiotherapy (IMRT) were administered twice daily over 5 weeks. Prescribed total dose/dose per fraction for planning target volume (PTVtumor) were 70 Gy in 1.4 Gy fractions, 72.5 Gy in 1.45 Gy fractions, and 75 Gy in 1.5 Gy fractions for 10, 13, and 16 patients, respectively. Uninvolvedlymphatic nodes (PTVuninvolved) were irradiated with 55 Gy in 1.1 Gy fractions using the concomitant integrated boost. Acute toxicity was evaluated according to the RTOG/EORTC scale; the incidence of grade 3 mucositis was 51% in the oral

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Strahlentherapie und Onkologie

  • ISSN

    0179-7158

  • e-ISSN

  • Volume of the periodical

    188

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    5

  • Pages from-to

    666-670

  • UT code for WoS article

    000306595500004

  • EID of the result in the Scopus database