Vancomycin removal during low-flux and high-flux extended daily hemodialysis in critically ill septic patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F12%3A00102876" target="_blank" >RIV/00843989:_____/12:00102876 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/12:33138910

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2012.002" target="_blank" >http://dx.doi.org/10.5507/bp.2012.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2012.002" target="_blank" >10.5507/bp.2012.002</a>

Result language

angličtina

Original language name

Vancomycin removal during low-flux and high-flux extended daily hemodialysis in critically ill septic patients

Original language description

Aims: To determine the extent of vancomycin removal and vancomycin pharmacokinetics in septic patients with AKI using daily hemodialysis with polysulphone high-flux and low-flux membrane. Methods: Five patients received 6 h daily dialysis with low-flux polysulphone membrane, four patients with high-flux polysulphone membrane. Vancomycin was administered over the last hour of dialysis. The maintenance dose was adjusted based on pre-hemodialysis serum concentrations. Patients were followed up for two days. Results: Median percentage of vancomycin removal by low-flux membrane dialysis was 17% (8-38%) and by high-flux membrane dialysis was 31% (13-43%). Vancomycin clearance was only moderately higher in high-flux membrane dialysis (median 3.01 L/h, range 2.34-3.5 L/h) compared to low-flux dialysis (median 2.48 L/h, range 0.53-5.68 L/h) in the first day of the study. About two-fold higher vancomycin clearance in high-flux dialysis (median 3.62 L/h, range 1.37-5.07 L/h) was observed on the s

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

<a href="/en/project/NS10309" target="_blank" >NS10309: Changes of pharmacokinetics of vancomycin and gentamicin in continual and intermittent elimination methods in sepsis and acute kidney insufficiency, the use of a predictive pharmacokinetic model in dosing of selected antibiotics.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

156

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

342-347

UT code for WoS article

000312983100010

EID of the result in the Scopus database

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