Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F13%3A00103187" target="_blank" >RIV/00843989:_____/13:00103187 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/13:A14019UL

Result on the web

<a href="http://dx.doi.org/10.1038/leu.2012.336" target="_blank" >http://dx.doi.org/10.1038/leu.2012.336</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/leu.2012.336" target="_blank" >10.1038/leu.2012.336</a>

Result language

angličtina

Original language name

Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group

Original language description

Plasma cell leukemia (PCL) is a rare and aggressive variant of myeloma characterized by the presence of circulating plasma cells. It is classified as either primary PCL occurring at diagnosis or as secondary PCL in patients with relapsed/refractory myeloma. Primary PCL is a distinct clinic-pathological entity with different cytogenetic and molecular findings. The clinical course is aggressive with short remissions and survival duration. The diagnosis is based upon the percentage (&amp;#8805; 20%) and absolute number (&amp;#8805; 2 × 10(9)/l) of plasma cells in the peripheral blood. It is proposed that the thresholds for diagnosis be re-examined and consensus recommendations are made for diagnosis, as well as, response and progression criteria. Induction therapy needs to begin promptly and have high clinical activity leading to rapid disease control in an effort to minimize the risk of early death. Intensive chemotherapy regimens and bortezomib-based regimens are recommended followed by

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia

ISSN

0887-6924

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

n. 4

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

"p. 780-791"

UT code for WoS article

000317472200005

EID of the result in the Scopus database

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