Clinically important interaction betweenmetoprolol and propafenone

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F13%3AE0103373" target="_blank" >RIV/00843989:_____/13:E0103373 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/13:A14019WF

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Clinically important interaction betweenmetoprolol and propafenone

Original language description

A combination of antiarrhythmic drugs with ß1 selective blocking agents has often been used. Both these types of drugs are metabolized via the cytochrome P450 (CYP) enzyme system, and therefore potential drug interactions are of considerable clinical significance. The antiarrhythmic agent propafenone undergoes CYP 2D6?dependent metabolism. Propafenone is also an inhibitor of the enzyme; the inhibitory constant has been estimated at 50 nmol/L, similar to that of quinidine (60 nmol/L). Metoprolol, a ß1 selective blocking agent, undergoes extensive presystemic elimination by CYP 2D6, and it has been shown that metabolites do not substantially contribute to the ß1-blockade. Metoprolol has a dose-dependent effect; dose is commonly titrated to the highest dose tolerated in order to achieve the maximal effect in the absence of adverse effects. A 2- to 5-fold increase in steady-state levels of metoprolol has been described after adding propafenone to metoprolol therapy. The disposition of CYP

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Canadian family physician

ISSN

0008-350X

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

n. 4

Country of publishing house

CA - CANADA

Number of pages

3

Pages from-to

"p. 373-375"

UT code for WoS article

000317812300014

EID of the result in the Scopus database

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