Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F02%3A51020140" target="_blank" >RIV/61388998:_____/02:51020140 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs.
Original language description
Ionic currents recorded in voltage clamp experiments on enzymatically isolated rat ventricular myocytes were analyzed with the aim to study the voltage and frequency dependence of sodium current block induced by two antiarrhythmic drugs: ajmaline and propafenone. The levels of block produced by both examined agents were clearly related to membrane voltage. Interestingly, ajmaline, in contrast to propafenone, did not show frequency and use dependent effect. These differences are analyzed.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Analysis of Biomedical Signals and Images.
ISBN
80-214-2120-7
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
214-216
Publisher name
Brno University of Technology
Place of publication
Brno
Event location
Brno [CZ]
Event date
Jun 26, 2002
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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