Ajmaline-induced block of sodium current in rat ventricular myocytes.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F02%3A51020083" target="_blank" >RIV/61388998:_____/02:51020083 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/02:00007153
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Ajmaline-induced block of sodium current in rat ventricular myocytes.
Original language description
The aim of the present study was to explore concentration-, voltage- and frequency-dependence of the sodium current (INa) block induced by ajmaline in enzymatically isolated rat ventricular myocytes. Voltage clamp experiments in whole-cell patch-clamp arrangement were performed on 32 cells. The blocking effect was evaluated in the range of concentrations between 0.3 and 5000 mmol/l at room temperature. The level of block was concentration-dependent and the effect was fully reversible. Pooled data analysis (18 cells and 25 measurements) resulted in EC50 = 8.2 1.5 mmol/l and the Hill coefficient of 0.62 0.08. The voltage- and frequency-dependence of the drug effect was analysed at 3 mmol/l. The block appeared to be voltage-dependent but frequency-independent in contrast to propafenone (0.2 mmol/l). An analysis of the rate of block level variations in response to voltage steps revealed substantial differences between kinetics of the block development in both drugs that corresponded well w
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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