<A >prospective, randomized, placebo-controlled, double-blind trial about safety and efficacy of combined treatment with alteplase (rt-PA) and Cerebrolysin in acute ischaemic hemispheric stroke

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F13%3AE0104042" target="_blank" >RIV/00843989:_____/13:E0104042 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1747-4949.2012.00901.x" target="_blank" >http://dx.doi.org/10.1111/j.1747-4949.2012.00901.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1747-4949.2012.00901.x" target="_blank" >10.1111/j.1747-4949.2012.00901.x</a>

Result language
angličtina
Original language name
<A >prospective, randomized, placebo-controlled, double-blind trial about safety and efficacy of combined treatment with alteplase (rt-PA) and Cerebrolysin in acute ischaemic hemispheric stroke
Original language description
Background The neurotrophic drug Cerebrolysin accelerated recovery and prevented acute neuronal damage in preclinical models of ischaemia. Previous clinical trials support therapeutic effects in stroke patients. The study investigated whether the combination with alteplase and Cerebrolysin is safe and can further reduce disability after acute ischaemic stroke. Methods This placebo-controlled, double-blind trial involved 119 patients with acute ischaemic hemispheric stroke, randomly assigned to a combined treatment with alteplase plus Cerebrolysin or placebo (administered 1?h after thrombolytic treatment) starting within three-hours after onset of symptoms. A daily i.v. infusion of 30?ml Cerebrolysin or placebo was given for 10 consecutive days. Primaryoutcome was the modified Rankin Scale at day 90. A sequential design with interim analyses was applied. Results The third interim analysis did not show a benefit in the modified Rankin Scale for Cerebrolysin on day 90 compared to placebo
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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