Circuit lifetime with citrate versus heparin in pediatric continuous venovenous hemodialysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F16%3AE0105564" target="_blank" >RIV/00843989:_____/16:E0105564 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/PCC.0000000000000860" target="_blank" >http://dx.doi.org/10.1097/PCC.0000000000000860</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PCC.0000000000000860" target="_blank" >10.1097/PCC.0000000000000860</a>
Alternative languages
Result language
angličtina
Original language name
Circuit lifetime with citrate versus heparin in pediatric continuous venovenous hemodialysis
Original language description
OBJECTIVES: To determine if there is a difference between regional citrate and global heparinized anticoagulation on circuit lifetimes during continuous venovenous hemodialysis in children. DESIGN: Prospective "cross-over" trial. SETTING: PICU, Department of Pediatrics, University Hospital Ostrava. PATIENTS: Children 0-18 years old. INTERVENTIONS: From 2009 to 2014, 63 eligible children (age, 89.24?±?62.9 mo; weight, 30.37?±?20.62?kg) received at least 24 hours of continuous venovenous hemodialysis. Each child received four continuous venovenous hemodialysis circuits with anticoagulants in the following order: heparin, citrate, heparin, citrate. Circuit life ended when transmembrane pressure was greater than or equal to 250?mm Hg for more than 60 minutes. MEASUREMENTS AND MAIN RESULTS: The total mean circuit lifetime was 39.75?±?10.73 hours. Citrate had a significantly longer median circuit lifetime (41.0?hr; CI, 37.6-44.4) than heparin (36.0?hr; CI, 35.4-36.6; p = 0.0001). Mortality was 33.33%. Circuit lifetime was significantly correlated to patient age (r = 0.606), weight (r = 0.763), and blood flow rate (r = 0.697). Transfusion rates (units of red cells per circuit of continuous venovenous hemodialysis) were 0.17 (0.0-1.0) with citrate and 0.36 (0.0-2.0) with heparin (p = 0.002). CONCLUSIONS: We showed in our study that citrate provided significantly longer circuit lifetimes than heparin for continuous venovenous hemodialysis in children. Citrate was superior to heparin for the transfusion requirements. Citrate was feasible and safe in children and infants.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric critical care medicine
ISSN
1947-3893
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
n. 9
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
"e399"-"e405"
UT code for WoS article
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EID of the result in the Scopus database
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