Matrix metalloproteinases MMP-3 and MMP-9 as predictors of in-stent restenosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F17%3AE0106751" target="_blank" >RIV/00843989:_____/17:E0106751 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Matrix metalloproteinases MMP-3 and MMP-9 as predictors of in-stent restenosis
Original language description
The present study aimed to demonstrate the use of matrix metalloproteinases (MMP-2, MMP-3 and MMP-9) as possible additional biochemical predictors of in-stent restenosis (ISR) and determined their reference intervals in adults with respect to gender and age. We included 111 consecutive patients treated at the cathlab of the University Hospital Ostrava, Czech Republic, with ISR within 12 months after implantation of a bare-metal stent. The control group consisted of 111 matched patients with identical main demographic and clinical risk factors. To set the reference intervals for MMPs, we measured the blood concentrations of these analytes in a group of healthy volunteers (N = 180) with an average age of 40–50 years. The enzyme concentrations were measured by immunosorbent assay. Statistical analysis was performed using IBM SPSS Statistics version 22 and MedCalc Version 14.12. We found that increased levels of MMP-3 and 9 were associated with a significant increase in ISR risk. The MMP-9 cut-off value for ISR risk prediction was determined to be ?64.8 ng/mL. We suppose that screening of these biochemical parameters might be helpful to a more detailed risk stratification of patients after percutaneous coronary interventions, who would be able to benefit from implantation of drug-eluting stents.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
The role of matrix metalloproteinase in human body pathologies
ISBN
978-953-51-3717-7
Number of pages of the result
13
Pages from-to
57-69
Number of pages of the book
190
Publisher name
InTech,
Place of publication
Rijeka, Croatia : InTech, 2017
UT code for WoS chapter
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