Impact of multiphase computed tomography angiography for endovascular treatment decision-making on outcomes in patients with acute ischemic stroke

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F21%3AE0109206" target="_blank" >RIV/00843989:_____/21:E0109206 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00123032

Result on the web

<a href="https://www.j-stroke.org/upload/pdf/jos-2021-00619.pdf" target="_blank" >https://www.j-stroke.org/upload/pdf/jos-2021-00619.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5853/jos.2021.00619" target="_blank" >10.5853/jos.2021.00619</a>

Result language

angličtina

Original language name

Impact of multiphase computed tomography angiography for endovascular treatment decision-making on outcomes in patients with acute ischemic stroke

Original language description

Background and purpose: Various imaging paradigms are used for endovascular treatment (EVT) decision-making and outcome estimation in acute ischemic stroke (AIS). We aim to compare how these imaging paradigms perform for EVT patient selection and outcome estimation. Methods: Prospective multi-center cohort study of patients with AIS symptoms with multi-phase computed tomography angiography (mCTA) and computed tomography perfusion (CTP) baseline imaging. mCTA-based EVT-eligibility was defined as presence of large vessel occlusion (LVO) and moderate-to-good collaterals on mCTA. CTP-based eligibility was defined as presence of LVO, ischemic core (defined on relative cerebral blood flow, absolute cerebral blood flow, and cerebral blood volume maps) <70 mL, mismatch-ratio >1.8, absolute mismatch >15 mL. EVT-eligibility and adjusted rates of good outcome (modified Rankin Scale 0-2) based on these imaging paradigms were compared. Results: Of 289/464 patients with LVO, 263 (91%) were EVT-eligible by mCTA-criteria versus 63 (22%), 19 (7%) and 103 (36%) by rCBF, aCBF, and CBV-CTP-criteria. CTP and mCTA-criteria were discordant in 40% to 53%. Estimated outcomes were best in patients who met both mCTA and CTP eligibility-criteria and were treated with EVT (62% to 87% good outcome). Patients eligible for EVT by mCTA-criteria and not by CTP-criteria receiving EVT achieved good outcome rates of 53% to 57%. Few patients met CTP-criteria and not mCTA-criteria for EVT. Conclusions: Simpler imaging selection criteria that rely on little else than detection of the occluded blood vessel may be more sensitive and less specific, thus resulting in more patients being offered EVT and arguably benefiting from it.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of stroke

ISSN

2287-6391

e-ISSN

2287-6405

Volume of the periodical

23

Issue of the periodical within the volume

3

Country of publishing house

KR - KOREA, REPUBLIC OF

Number of pages

11

Pages from-to

377-387

UT code for WoS article

000703882200007

EID of the result in the Scopus database

2-s2.0-85120714320