FMISO-based adaptive radiotherapy in head and neck cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0109681" target="_blank" >RIV/00843989:_____/22:E0109681 - isvavai.cz</a>
Alternative codes found
RIV/00098892:_____/22:10157168 RIV/61989592:15110/22:73614704 RIV/00209805:_____/22:00079051 RIV/00216224:14110/22:00128261 RIV/61988987:17110/22:A2402KED
Result on the web
<a href="https://www.mdpi.com/2075-4426/12/8/1245" target="_blank" >https://www.mdpi.com/2075-4426/12/8/1245</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/jpm12081245" target="_blank" >10.3390/jpm12081245</a>
Alternative languages
Result language
angličtina
Original language name
FMISO-based adaptive radiotherapy in head and neck cancer
Original language description
Concurrent chemoradiotherapy represents one of the most used strategies in the curative treatment of patients with head and neck (HNC) cancer. Locoregional failure is the predominant recurrence pattern. Tumor hypoxia belongs to the main cause of treatment failure. Positron emission tomography (PET) using hypoxia radiotracers has been studied extensively and has proven its feasibility and reproducibility to detect tumor hypoxia. A number of studies confirmed that the uptake of FMISO in the recurrent region is significantly higher than that in the non-recurrent region. The escalation of dose to hypoxic tumors may improve outcomes. The technical feasibility of optimizing radiotherapeutic plans has been well documented. To define the hypoxic tumour volume, there are two main approaches: dose painting by contour (DPBC) or by number (DPBN) based on PET images. Despite amazing technological advances, precision in target coverage, and surrounding tissue sparring, radiation oncology is still not considered a targeted treatment if the “one dose fits all” approach is used. Using FMISO and other hypoxia tracers may be an important step for individualizing radiation treatment and together with future radiomic principles and a possible genome-based adjusting dose, will move radiation oncology into the precise and personalized era.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of personalized medicine
ISSN
2075-4426
e-ISSN
2075-4426
Volume of the periodical
12
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1-12
UT code for WoS article
000845752300001
EID of the result in the Scopus database
2-s2.0-85137386277