The imaging of the hypoxic microenvironment in tumorous tissue using PET/CT and PET/MRI
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10448690" target="_blank" >RIV/00669806:_____/22:10448690 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/22:10448690
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9ihiUemeDj" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9ihiUemeDj</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejrad.2022.110458" target="_blank" >10.1016/j.ejrad.2022.110458</a>
Alternative languages
Result language
angličtina
Original language name
The imaging of the hypoxic microenvironment in tumorous tissue using PET/CT and PET/MRI
Original language description
Tissue hypoxia becomes the driver of the micro-environmental transformation of the malignant tumorous tissue in majority of solid tumors. Even more, during the development of solid tumors, a large amount of nutrients is consumed due to rapid proliferation of tumor cells. The way of use of nutrients could be assessed using the probes during positron emission tomography (PET), the most frequent is the use of F-18-fluorodeoxyglucose (F-18-FDG) demonstrating the turn-over of glucose exploitation in a manner of Warburg phenomenon. Even tumor cells can undergo metabolic reprogramming by changing the expression of glycolysis-related proteins, development of hypoxic condition increases glucose uptake to promote their growth. The hypoxic conditions are stimulation also the development of drug and/or radiation resistance, thus, the identification of the hypoxic tissue could play an important role in therapy planning. The process that enables use of hypoxia specific PET radiopharmaceutical starts when it enters cell by passive diffusion. Intracellularly, a model substance -F-18-fluoromisonidazol (F-18-FMISO) is reduced by nitroreductase enzymes to become trapped in cells within reduced tissue oxygen partial pressure. The identification of the hypoxic tissue aids to plan the target to radiotherapy in squamous cell car-cinomas of head and neck or cervical carcinoma, when F-18-FMISO-PET/CT is used as a planning procedure for a target volume, while F-18-FDG-PET/MRI is being the local and whole body staging procedure. Hypoxia imaging helps to identify the high-grade component of an astrocytic tumor before stereotactic biopsy. <comment>Superscript/Subscript Available</comment
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Radiology
ISSN
0720-048X
e-ISSN
1872-7727
Volume of the periodical
154
Issue of the periodical within the volume
September
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
110458
UT code for WoS article
000859871900001
EID of the result in the Scopus database
2-s2.0-85135407256