Subgroup analysis based on cytogenetic risk in patients with relapsed or refractory multiple myeloma in the CANDOR study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0109727" target="_blank" >RIV/00843989:_____/22:E0109727 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/22:A2302J5G
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/bjh.18233" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/bjh.18233</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bjh.18233" target="_blank" >10.1111/bjh.18233</a>
Alternative languages
Result language
angličtina
Original language name
Subgroup analysis based on cytogenetic risk in patients with relapsed or refractory multiple myeloma in the CANDOR study
Original language description
CANDOR compared the safety/efficacy of carfilzomib with dexamethasone and daratumumab (KdD) to carfilzomib with dexamethasone (Kd) in adults with relapsed/refractory multiple myeloma (RRMM). This CANDOR subgroup analysis evaluated outcomes based on cytogenetic risk. Overall response rates (KdD vs. Kd) were 81% versus 56% in high-risk and 87% versus 79% in standard-risk groups. Median progression-free survival was 11.2 versus 7.4 months in high-risk (hazard ratio, 0.56 [95% CI, 0.34, 0.93]) and not reached versus 16.6 months in standard-risk groups (0.56 [95% CI, 0.39, 0.80]). These data support the efficacy of KdD in RRMM treatment, including in patients with high-risk cytogenetics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British journal of haematology
ISSN
0007-1048
e-ISSN
1365-2141
Volume of the periodical
198
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
988-993
UT code for WoS article
000801014600001
EID of the result in the Scopus database
2-s2.0-85130430549