Deubiquitinase OTUD1 resolves stalled translation on polyA and rare codon rich mRNAs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0110035" target="_blank" >RIV/00843989:_____/22:E0110035 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/22:A2302IYW
Result on the web
<a href="https://journals.asm.org/doi/10.1128/mcb.00265-22" target="_blank" >https://journals.asm.org/doi/10.1128/mcb.00265-22</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/mcb.00265-22" target="_blank" >10.1128/mcb.00265-22</a>
Alternative languages
Result language
angličtina
Original language name
Deubiquitinase OTUD1 resolves stalled translation on polyA and rare codon rich mRNAs
Original language description
OTUD1 is a deubiquitinating enzyme involved in many cellular processes including cancer and innate, immune signaling pathways. Here, we perform a proximity labeling-based interactome study that identifies OTUD1 largely present in the translation and RNA metabolism protein complexes. Biochemical analysis validates OTUD1 association with ribosome subunits, elongation factors and the E3 ubiquitin ligase ZNF598 but not with the translation initiation machinery. OTUD1 catalytic activity suppresses polyA triggered ribosome stalling through inhibition of ZNF598-mediated RPS10 ubiquitination and stimulates formation of polysomes. Finally, analysis of gene expression suggests that OTUD1 regulates the stability of rare codon rich mRNAs by antagonizing ZNF598.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and cellular biology
ISSN
0270-7306
e-ISSN
1098-5549
Volume of the periodical
42
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1-10
UT code for WoS article
000891958800001
EID of the result in the Scopus database
2-s2.0-85144840748