Acquired haemophilia as a complicating factor in treatment of non-muscle invasive bladder cancer: A case report

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110361" target="_blank" >RIV/00843989:_____/23:E0110361 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/23:A2402N2L
Result on the web
<a href="https://www.wjgnet.com/2307-8960/full/v11/i22/5338.htm" target="_blank" >https://www.wjgnet.com/2307-8960/full/v11/i22/5338.htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.12998/wjcc.v11.i22.5338" target="_blank" >10.12998/wjcc.v11.i22.5338</a>

Result language
angličtina
Original language name
Acquired haemophilia as a complicating factor in treatment of non-muscle invasive bladder cancer: A case report
Original language description
Background: Acquired haemophilia (AH) is a serious autoimmune haematological disease caused by the production of auto-antibodies against coagulation factor VIII. In some patients, AH is associated with a concomitant malignancy. In case of surgical intervention, AH poses a high risk of life-threatening bleeding. Case summary: A 60-year-old female patient with multiple recurrences of non-muscle invasive bladder cancer underwent transurethral tumour resection. A severe haematuria developed postoperatively warranting two endoscopic revisions; however, no clear source of bleeding was identified in the bladder. Subsequent haematological examination established a diagnosis of AH. Treatment with factor VIII inhibitor bypass activity and immunosuppressive therapy was initiated immediately. The patient responded well to the therapy and was discharged from the hospital 21 d after the primary surgery. At the 38-mo follow-up, both AH and bladder cancer remained in complete remission. Conclusion: AH is a rare, life-threatening haematological disease. AH should be considered in patients with persistent severe haematuria or other bleeding symptoms, especially if combined with isolated activated partial thromboplastin time prolongation.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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