L1CAM is not a predictive factor in early-stage squamous-cell cervical cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110372" target="_blank" >RIV/00843989:_____/23:E0110372 - isvavai.cz</a>

Result on the web

<a href="https://iv.iiarjournals.org/content/37/5/2334" target="_blank" >https://iv.iiarjournals.org/content/37/5/2334</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/invivo.13337" target="_blank" >10.21873/invivo.13337</a>

Result language

angličtina

Original language name

L1CAM is not a predictive factor in early-stage squamous-cell cervical cancer

Original language description

Aim: Our study aimed to assess expression of L1 cell adhesion molecule (L1CAM) in early-stage cervical squamous-cell cancer as a prognostic factor. Patients and methods: This retrospective, single-institution study included 154 patients who underwent radical hysterectomy for early-stage squamous cell cervical cancer between 2007 and 2017. Tumor samples from 154 patients were available for L1CAM analysis by immunohistochemistry. Among all patients, radical abdominal hysterectomy was performed in 144 cases. Results: L1CAM expression was positive in 24 tumors (15.6%) of the whole group. In relation to the grade of differentiation and the presence of lymphovascular invasion, L1CAM expression did not show an association (p=0.154 and p=0.306, respectively). The disease-free interval and overall survival also did not significantly differ between L1CAM-positive and L1CAM-negative cases (p=0.427 and p=0.240, respectively). For histopathological characteristics, L1CAM-positive cases had a significantly higher median tumor size (p=0.015). Even in the selected group of 115 cases without nodal infiltration, L1CAM status had no effect on the relapse rate during follow-up. Conclusion: Our study did not confirm the results of previous studies showing L1CAM expression to be a negative prognostic factor in cervical cancer. In our study, increased L1CAM expression in early-stage squamous-cell cervical cancer was not associated with adverse prognosis regarding disease recurrence, disease-free survival, nor overall survival. L1CAM expression was correlated only with the size of the tumor.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

In vivo

ISSN

0258-851X

e-ISSN

1791-7549

Volume of the periodical

37

Issue of the periodical within the volume

5

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

2334-2339

UT code for WoS article

001108917300012

EID of the result in the Scopus database

2-s2.0-85169409836