L1CAM as a Negative Prognostic Factor in Endometrioid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F19%3AA21025OV" target="_blank" >RIV/61988987:17110/19:A21025OV - isvavai.cz</a>
Result on the web
<a href="http://ar.iiarjournals.org/content/39/1/421" target="_blank" >http://ar.iiarjournals.org/content/39/1/421</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/anticanres.13128" target="_blank" >10.21873/anticanres.13128</a>
Alternative languages
Result language
angličtina
Original language name
L1CAM as a Negative Prognostic Factor in Endometrioid
Original language description
Aims: In this study, we aimed to investigate how positivity for L1 cell adhesion molecule (L1CAM) was associated with outcome and relapse pattern in patients with Federation Internationale de Gynecologie et d'Obstetrique (FIGO) stage IA-IB endometrial cancer. Materials and Methods: This retrospective study included 358 patients who underwent surgical treatment for endometrial carcinoma. Tumor samples from 312 patients (87.2%) were available for L1CAM analysis by immunohistochemistry. Results: Of the 312 tumor samples analyzed, 93 (29.8%) were L1CAM-positive. L1CAM positivity was significantly more common in grade 3 compared to grade 1-2 carcinomas (p=0.02). Patients with L1CAM positivity more commonly experienced disease progression. Distant metastasis was significantly associated with L1CAM positivity (p=0.01). Progression-free interval and overall survival did not significantly differ between L1CAM-positive and L1CAM-negative cases. Conclusion: L1CAM is a promising independent prognostic marker associated with aggressive tumor behavior and recurrence risk, but not with overall survival.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ANTICANCER RESEARCH
ISSN
0250-7005
e-ISSN
1791-7530
Volume of the periodical
39
Issue of the periodical within the volume
1
Country of publishing house
GR - GREECE
Number of pages
3
Pages from-to
421-424
UT code for WoS article
000454413400055
EID of the result in the Scopus database
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